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Oral Molecular Pathophysiology

Cordeliers ‘s research Center, Paris.

Oral diseases are a major health concern. They include frequent infectious diseases, common acquired dental developmental defects, rare genetic diseases and tumors.  Our team explores oral physiology and pathology from bench to bedside. Our goal is to identify and characterize distinct molecular pathways driving jaw-tooth biology

Our Carrers

An opportunity to train with experimental approach
Experimental Approach

Methods for proteins visualization in dental mineralized tissues.
Hotton. D, Berdal. A and Bolanos. A.
Odontogenesis Protocols Book
Springerlag Editor.2019. 1922; 173-180

In situ Hybridization in mineralized tissues: the added value of LNA probes for RNA detection
Lignon. G, Hotton.D, Berdal. A and Bolanos. A.
Odontogenesis Protocols Book.
Springerlag Editor. 2019.1922; 181-190

Recent publications

2020

Merzoug-Larabi M, Youssef I, Bui AT, Legay C, Loiodice S, Lognon S, Babajko S, Ricort JM
Protein Kinase D1 (PKD1) Is a New Functional Non-Genomic Target of Bisphenol A in Breast Cancer Cells.
Front Pharmacol. 2020 Jan 31;10:1683.

Gama A, Maman L, Vargas-Franco JW, Omar R, Royer BB, Yagita H, Babajko S, Berdal A, Acevedo AC, Heymann D, Lézot F, Castaneda B.
Primary Retention of Molars and RANKL Signaling Alteration during Craniofacial Growth.
J Clin Med. 2020; 9(4).

Abdal-Hay A, Thattaruparambil Raveendran N, Fournier B, Ivanovski S.
Fabrication of Biocompatible and Bioabsorbable Polycaprolactone/ Magnesium Hydroxide 3D Printed Scaffolds: Degradation and in vitro Osteoblasts Interactions. Composites Part B: Engineering. 2020,

Babajko S, Gayrard V, Houari S, Thu Bui A, Barouki R, Niederreither K, Fini JB, Dursun E, Coumoul X.
`{`Oral cavity as a target and a marker of environmental exposures: developmental dental defects`}`.
Med Sci (Paris). 2020;36(3):225-230.

Babajko S, Lescaille G, Radoï L, Thu Bui A, Baaroun V, Boyer E, Delbosc S,Chardin H, Barouki R, Coumoul X.
`{`Oral cavity as a target and a marker ofenvironmental exposures: diseases diagnosed during adulthood`}`.
Med Sci (Paris).2020;36(3):231-234.

Gama A, Vargas-Franco JW, Sánchez Mesa DC, Restrepo Bedoya E, Amiaud J, Babajko S, Berdal A, Acevedo AC, Heymann D, Lézot F, Castaneda B.
Origins of Alterations to Rankl Null Mutant Mouse Dental Root Development.
Int J Mol Sci.2020;21(6). 2019

Lignon G, Hotton D, Berdal A, Bolaños A.
In Situ Hybridization in Mineralized Tissues: The Added Value of LNA Probes for RNA Detection.
Methods Mol Biol. 2019;1922:181-190.

Hotton D, Berdal A, Bolaños A.
Methods for In Situ Protein Visualization in Dental Mineralized Tissues.
Methods Mol Biol. 2019;1922:173-180.

Youssef I, Ricort JM. Deciphering the Role of Protein Kinase D1 (PKD1) in Cellular Proliferation.
Mol Cancer Res. 2019;17(10):1961-1974.

Chekroun M, Cherifi H, Fournier B, Gaultier F, Sitbon IY, Ferre FC, Gogly B. 2019.
Oral manifestations of sickle cell disease.
Br Dent J. 226(1):27-31.

de La Dure-Molla M, Fournier BP, Manzanares MC, Acevedo AC, Hennekam RC, Friedlander L, Boy-Lefèvre ML, Kerner S, Toupenay S, Garrec P, Vi-Fane B, Felizardo R, Berteretche MV, Jordan L, Ferré F, Clauss F, Jung S, de Chalendar M, Troester S, Kawczynski M, Chaloyard J; International Group of Dental Nomenclature, Manière MC, Berdal A, Bloch-Zupan A.
Elements of morphology: Standard terminology for the teeth and classifying genetic dental disorders.
Am J Med Genet A. 2019;179(10):1913-1981.

Friedlander L, Berdal A, Boizeau P, Licht BA, Manière MC, Picard A, Azzis O, Vazquez MP, Alberti C, Molla MD.
Oral health related quality of life of children and adolescents affected by rare orofacial diseases: a questionnaire-based cohort study.
Orphanet J Rare Dis. 2019;14(1):124. doi: 10.1186/s13023-019-1109-2
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6549379/

Gama A, Perea L, Yepes C, Betancur JJ, Vargas J, Amiaud J, Babajko S, Lezot F, Castaneda B.
`{`Effects of post-natal inhibition of RANKL on molar eruption and root formation in C57BL/6 mice`}`.
Orthod Fr. 2019;90(1):55-63.

Houari S, Picard E, Wurtz T, Vennat E, Roubier N, Wu TD, Guerquin-Kern JL, Duttine M, Thuy TT, Berdal A, Babajko S.
Disrupted Iron Storage in Dental Fluorosis.
J Dent Res. 2019;98(9):994-1001. d

Jordan L, Beydon N, Razanamihaja N, Garrec P, Carra MC, Fournier BP, Vi-Fane B, Kerner S, Felizardo R, Boy-Lefèvre ML, De La Dure-Molla M. Translation and cross-cultural validation of the French version of the Sleep-Related Breathing Disorder scale of the Pediatric Sleep Questionnaire. Sleep Med. 2019;58:123-129.

Korah L, Amri N, Bugueno IM, Hotton D, Tenenbaum H, Huck O, Berdal A, Davideau JL.
Experimental periodontitis in Msx2 mutant mice induces alveolar bone necrosis.
J Periodontol. 2019.

Perea-Gomez A, Cases O, Lelièvre V, Pulina MV, Collignon J, Hadjantonakis AK, Kozyraki R.
Loss of Cubilin, the intrinsic factor-vitamin B12 receptor, impairs visceral endoderm endocytosis and endodermal patterning in the mouse.
Sci Rep. 2019;9(1):10168.

Taïhi I, Nassif A, Isaac J, Fournier BP, Ferré F.
Head to Knee: Cranial Neural Crest-Derived Cells as Promising Candidates for Human Cartilage Repair.
Stem Cells Int. 2019;2019:9310318.

Vutipongsatorn K, Nagaoka N, Yokoi T, Yoshida T, Kamoi K, Horie S, Uramoto K, Hirata A, Occelli LM, Petersen-Jones SM, Montiani-Ferreira F, Cases O, Kozyraki R, Jonas JB, Ohno-Matsui K.
Correlations Between Experimental Myopia Models And Human Pathologic Myopia.
Retina. 2019;39(4):621-635.

Nationally and Internationally recognized

2018
North Ecos contract
France - Colombia. C18S01.
2018/2020 A.Berdal, S.Babajko, D.Hotton and A.Bolanos

CAPES COFECUB
France- Brazil . Me 915/18
2018/2021 A.Berdal, D.Hotton and A.Bolanos

International funding France/Thailand:
Junior Research Fellowship Program 2018

2017
ADF Prize awarded to Ali Nassif supervised by B. Fournier/B Gogly/S Babajko for his thesis.

Award for the best thesis of the Val de Marne for L. Loison Robert directed by B. Fournier and B. Gogly.

ANCD Award for Ali Nassif directed by B. Gogly, B. Fournier and S. Babajko.

Best Presentation Award, ETRS 2017, Brussels to Ihsène Taihi directed by B. Fournier/B Gogly.

Award for the best presentation, Garancière Research Day to Ali Nassif directed by B. Fournier

Award for the best artistic scientific photo, Garancière à C. Rémond Research Day, supervised by B. Fournier

Master's degree BCPP

Research speciality « biomineralization, morphogenesis and inflammatory pathologies » (BMIP)

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Master BCPP

Professional field “oral pathophysiology applied” (OPA)

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European University Diploma of Endodontology

Dental school Garancière (University Paris Diderot - Paris 7)

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News & Events

5th National Head and Neck Day Rare malformations of the head, neck and teeth Friday, October 2, 2020.

Due to the health situation, the Day will be virtual, with live broadcasting of the conferences and remote exchanges.

Defense of doctoral thesis of Andrea Gama Silva

Friday 29 November saw the defense of Andrea Gama Silva’s doctoral thesis: “Study of RANKL’s involvement in craniofacial skeletal growth on two …

Read MoreDefense of doctoral thesis of Andrea Gama Silva

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