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Seminar at the Faculty of Dentistry (Garancière) Title: Dental Pulp Tissue Engineering, Friday, September 21, 9:30 am

Kerstin GALLER

University Hospital Regensburg, Germany is invited by Pr Stéphane SIMON (EQ Berdal) at the UFR of Odontology(Faculty of Dentistry)

at 9:30 am Salle Bonaparte, 5 rue Garancière 75006 Paris

Dr. Galler is currently Associate Professor and leader of the section of Endodontology and Dental Traumatology at the University of Regensburg. Her time is divided between clinical work with focus on endodontology, teaching as lecturer and clinical instructor, and research. Her research group works on tunable hydrogel scaffolds and dental stem cells for dental pulp tissue engineering and regenerative endodontics, on dentin matrix proteins and on biofilm-associated reactions of different pulp cell populations.

Dr. Galler was President of the Pulp Biology and Regeneration Group of IADR in 2013/14, and led the committee for the ESE Position Statement on Revitalization. She has published numerous articles in the field of pulp biology and dental pulp tissue engineering, received several awards for her scientific work and has lectured extensively nationally and internationally in clinical as well as scientific meetings.

The Dental Pulp – Vital Therapy, Revitalization and Regeneration

The loss of dental pulp implicates the loss of tissue function, such as nociception and mechanotransduction, immunoresponse, formation of dentin as an active defense mechanism against invading toxins and bacteria, and, in the special case of young patients, completion of root formation. Regular root canal therapy involves the removal or pulp tissue, cleaning, shaping and obturation with a synthetic material.

With advances in the fields of pulp biology, stem cells and tissue engineering, more biology-based treatment approaches are considered today. In the case of partial pulpitis, vital pulp therapy such as pulp capping or pulpotomy can be performed in order to keep the tooth vital. In the case of pulp necrosis, new treatment protocols exist for teeth with incomplete root formation, where revitalization is a viable alternative to conventional apexification. For the future, tissue engineering approaches using stem cells, bioactive scaffold materials and growth factors might be useful to repair or even regenerate dental pulp also in teeth with complete root formation.

This lecture will cover aspects of basic pulp biology, suggest an extension of the classical indication for vital pulp therapy, go over the currently recommended protocols for revitalization and discuss an envisioned protocol for a tissue engineering approach to regenerate dental pulp in the future.

Abstract of the seminar

Engineering oral tissues as a multidisciplinary approach to build structures such as the dentin-pulp complex remains a challenging endeavor. In vivo-research provides proof that the generation of a pulp-like tissue is possible after application of the principle of tissue engineering, which involves the use of stem cells, suitable scaffold materials and relevant growth factors. Two approaches exist: (1) Transplantation of stem cells on a growth factor – laden carrier material into the root canal ; and (2) Cell-Homing by application of a customized, bioactive scaffold after release of growth factors to attract resident stem cells for new tissue formation. This lecture will provide an overview of the literature regarding dental pulp tissue engineering, cover the cell types involved in dental pulp regeneration, discuss requirements for scaffold materials, touch upon growth factors, and envision a clinical procedure to regenerate pulp in the future.