The laboratory “Oral Molecular Pathophysiology” was created in January 2001, emerging from the University Paris-Diderot dental school. This is an INSERM ( Institut National de la Santé Et de la Recherche Médicale) certified team in the Physiology and Pathophysiology Department in the Research Cordeliers Center. This laboratory is directed by Pr. Ariane BERDAL, DDS PhD and Dr. Sylvie BABAJKO, PhD. The team conducts oral translational oral researches with the objectives of understanding the developmental processes of oral tissues and pathologies, and to transfer the knowledge on innovative therapeutics (tissue engineering, pharmacology).
The team explores (1) gene-environment relationships (2), cellular pathways in rare diseases and (3) mesenchymal cells and biotherapies. Our goal is to delineate presently unknown integrative biological frames in jaws and promote innovative oral biotherapies. Site-specific regulatory pathways (transcription factor, matrix peptides) controlling mineral quality, cell fate and bone (re)modelling rates are analyzed due to original modelizations. Tooth and bone regeneration projects are based on the mimicry of the oral circuities. We identify, notably in (neural-crest vs mesoderm) lineage studies and ongoing Hospital Research PHRC program on vital pulp therapy or orthodontics
