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About the Lab

Unique Inserm team in Oral Molecular Pathophysiology

The laboratory “Oral Molecular Pathophysiology” was created in January 2001, emerging from the University Paris-Diderot dental school. This is an INSERM ( Institut National de la Santé Et de la Recherche Médicale) certified team in the Physiology and Pathophysiology Department in the Research Cordeliers Center. This laboratory  is directed by Pr. Ariane BERDAL, DDS PhD and Dr. Sylvie BABAJKO, PhD. The team conducts oral translational oral researches with the objectives of understanding the developmental processes of oral tissues and pathologies, and to transfer the knowledge on innovative therapeutics (tissue engineering, pharmacology). 

The team explores (1) gene-environment relationships (2), cellular pathways in rare diseases and (3) mesenchymal cells and biotherapies. Our goal is to delineate presently unknown integrative biological frames in jaws and promote innovative oral biotherapies. Site-specific regulatory pathways (transcription factor, matrix peptides) controlling mineral quality, cell fate and bone (re)modelling rates are analyzed due to original modelizations. Tooth and bone regeneration projects are based on the mimicry of the oral circuities. We identify, notably in (neural-crest vs mesoderm) lineage studies and ongoing Hospital Research PHRC program on vital pulp therapy or orthodontics

1 UNIQUE INSERM TEAM
166 PAPERS PUBLISHED
3 CAREERS TO DEVELOP YOURSELF IN

Our Location

Oral Molecular Pathophysiology Lab is located at the Research Cordeliers Center door E, 2nd floor. In the historical heart of Paris, the old Cordeliers Convent was built in the 6th district, at the crossroads of Quartier Latin and Saint Germain-des- Prés. A number of higher education establishments besides the university itself, such as the Sorbonne University, the Dental School Garancière, the Pierre and Marie Curie University, the Collège de France and the Ecole Normale Supérieure (ENS)