Start your Research cursus with us

Practical teaching introduction to Research

A program of training has a practice in the experimental approaches being a member of the level internship 4th year of university is proposed to prepare the students for their entrance to the program of Master 2. This internship must be completed by EU fundamental organized on the faculty and in Medicine. The laboratory welcomes students of other specialities of Master’s degree

Master's degree


MASTER “SCIENCES, TECHNOLOGIES, HEALTH                                                                              MENTION “BIOLOGY AND HEALTH

Presentation: The rare orofacial disease program includes: theoretical teaching, including lectures, seminars, discussion of clinical cases and literature reviews; and clinical and research teaching where students will acquire knowledge in the field of advanced diagnostics and complex treatments. The program also includes the development and, if possible, the implementation of a clinical research project by the student. Students complete a research, clinical or experimental internship related to the title of the specialty. Students with an odontological background may instead complete a clinical rotation in a hospital-based orofacial rare disease clinic.

The objective of the orofacial rare diseases program is to train students from various health and scientific backgrounds through a clinical approach.

In terms of public health, we observe an evolution of needs requiring the care of specific patients, notably disabilities or rare diseases. This demand has necessitated the creation of specialized centers and requires odontologists to deepen their skills. We also observe a therapeutic sophistication associated with the evolution of research in dentistry (use of growth factors, dental implants, etc.).

Targeted competencies

Know the craniofacial development and the stages of odontogenesis
Know how to recognize the symptoms of a rare oral disease
Know how to perform a clinical examination of a dysmorphic patient
Know the semiology and know how to diagnose an isolated and syndromic rare disease in collaboration with other medical disciplines
Know the etiology of rare diseases
Know the therapeutic specificities of rare diseases
Know the care pathway, the ethical and regulatory specificities related to rare diseases

Renata Kozyraki
Head of the diploma

Bruno Gogly
Head of the diploma

de la Dure Molla
Head of the diploma
Cécile Butor
Head of the diploma

Christophe Roca
Administrative contact
01 58 07 67 95


Competence block in oral pathophysiology (9 credits) S3
Mechanisms of oral physiopathology (UE 1), Clinical investigation and diagnosis in dentistry (UE 2)

Rare orofacial diseases block (6 credits) S3
Genetics and pathophysiology exploration (UE 3)

Rare orofacial diseases (genetics, skeletal anomalies, follow-up of rare orofacial diseases) (UE4)
Practical block in rare orofacial diseases (12 credits) S3
Scientific article project in rare orofacial diseases (UE5) and a choice of clinical internship in rare orofacial diseases (UE6a) or research internship in rare orofacial diseases (UE6b)
Out of block, Language block (3 credits)S3
English oral physiopathology (UE7a) or French oral physiopathology (UE 7b)

Rare orofacial diseases” block (9 credits) S4

Fetal genetic and tumor pathologies (UE8), Clinic of rare oro-facial diseases (UE9)

1 UE (UE 10) to be chosen among : Fetal internal organ pathologies (UE 10a), Maternal pathologies, fetal therapies (UE 10b), Therapeutic aspects of periodontal diseases (UE 10c), Therapeutic aspects of endodontic diseases (UE 10d), Cephalic pain syndromes (UE 10e)

Block ” In-depth practice in rare orofacial diseases ” (21 credits) S4

Dissertation in rare orofacial diseases (UE 11), 1 UE 12 to be chosen between: Clinical internship in rare orofacial diseases (UE 12a) or Research internship in rare orofacial diseases (UE 12b),), 1 UE 13 to be chosen between: Clinical case in rare orofacial diseases (UE 13a) or Research results in rare orofacial diseases (UE 13b)

Overall organization per semester

Starting period of the training: October
End of the training period : end of June
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Internships and tutored projects
A clinical training course or of clinical research in connection with the title of the course will be carried out in one of the services of odontology attached to the Universities of Paris Descartes or Paris Diderot under the responsibility of HU titular personnel specialized in rare diseases orofacial (3 centers of rare diseases) and having an activity of clinical research (MCU-PH, PU-PH). Alternatively, an experimental internship may be carried out in a laboratory related to the specialty.

Internship of 300 hours from October to the end of June

Control of knowledge
Control of knowledge

Written tests for the theoretical UE.
Oral test for UE 7, and UE 13
Evaluation of the scientific article project in rare oro-facial diseases (UE5) and of the clinical internship in rare oro-facial diseases (UE6a) or of the research internship in rare oro-facial diseases (UE6b) and of the UE12 of the student’s choice by a referent supervisor
Evaluation of a written thesis UE11.
Eliminatory mark in a UE, threshold mark for compensation: less than 9/20
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Special arrangements
Students with disabilities: yes
You can contact the Health & Disability Support Service by email (ash @ parisdescartes.fr) or by phone: 01 76 53 17 64.

Target audience
Students from various health and scientific backgrounds.

Admission requirements
To have completed the M1 in the Health field or an equivalent M1
To have completed an introductory course in research as part of dental studies with a clinical internship in rare oro-facial diseases (for those interested in a clinical internship in M2) or a research internship.
Very good level in cell biology, molecular biology, physiology and development or genetics.
300-hour research internship or (for odontologists wishing to do a clinical internship) in a hospital department dealing with rare diseases.
Good command of scientific English.
The exercise of care activities requires the prior validation of an odontological diploma.
How to apply
Contact the master’s secretariat in May-June
Selection interview in early July
Submission of applications on e-candidat August 25 – September 15

Master BCPP

Master's degree in health - Course: Rare oro-facial diseases
Field: Sciences, Technologies, Health

Dental School Garancière (University Paris Diderot - Paris 7)

Pr Stéphane SIMON   stephane.simon@u-paris.fr

Recurrent health crises (asbestos, dioxin, magnetic fields, bisphenol A,…) clearly highlight the close relations between man and his environment and the sometimes dramatic consequences of a poor health risk assessment. The development of new technologies and innovations in industry and research (e.g. nanotechnologies) mean that new substances are constantly being generated. Improving knowledge leads to the identification of emerging risks (e.g. endocrine disrupters) and the question of the effects of environments on health (general environment, professional environment, food) is a major concern. In order to meet the challenges related to human health, while respecting the environment, it is essential that education be provided that takes into account current toxicological and safety concerns (air and water quality, toxicological safety of foodstuffs, safety of working environments).

The “Toxicology, Environment, Health” (TES) course aims to train students from different origins (biologists, doctors, pharmacists, veterinarians, agronomists, environmental and chemical engineers as well as actors from the professional world. Thanks to this multidisciplinary training, the graduate will have solid scientific knowledge on the cellular and molecular mechanisms of action of environmental pollutants and their physio-pathological consequences, on the exposure modalities according to the considered environments (general and professional) and good bases in epidemiology and risk assessment.

He will also have professional skills (bibliographic analysis and synthesis, written and oral communication of experimental results, team work, ability to debate).


Sylvie Babajko’s team welcomes master students from the Master 2 « Toxicology, Environment and Hearth »


Master 2

Toxicology Enviroment and Health | Paris-Descarted University

We stand out!


Methods for proteins visualization in dental mineralized tissues.
Hotton. D, Berdal. A and Bolanos. A.
Odontogenesis Protocols Book
Springerlag Editor.2019. 1922; 173-180

In situ Hybridization in mineralized tissues: the added value of LNA probes for RNA detection
Lignon. G, Hotton.D, Berdal. A and Bolanos. A.
Odontogenesis Protocols Book.
Springerlag Editor. 2019.1922; 181-190


Simancas Escorcia V, Diarra A, Naveau A, Dessombz A, Felizardo R, Cannaya V, Chatziantoniou C, Quentric M, Vikkula M, Cases O, Berdal A, De La Dure-Molla M, Kozyraki R. Lack of FAM20A, Ectopic Gingival Mineralization and Chondro/Osteogenic Modifications in Enamel Renal Syndrome.
Front Cell Dev Biol. 2020 Dec 8

Koffi KA, Doublier S, Ricort JM, Babajko S, Nassif A, Isaac J. The Role of GH/IGF Axis in Dento-Alveolar Complex from Development to Aging and Therapeutics: A Narrative Review.
Cells. 2021 May 12;10(5):1181

Morice A, Joly A, Ricquebourg M, Maruani G, Durand E, Galmiche L, Amiel J, Vial Y, Cavé H, Belhous K, Piketty M, Cohen-Solal M, Berdal A, Collet C, Picard A, Coudert AE, Kadlub N. Cherubism as a systemic skeletal disease: evidence from an aggressive case.
BMC Musculoskelet Disord. 2020 Aug 21;21(1):564.

Gama A, Maman L, Vargas-Franco JW, Omar R, Royer BB, Yagita H, Babajko S, Berdal A, Acevedo AC, Heymann D, Lézot F, Castaneda B. Primary Retention of Molars and RANKL Signaling Alteration during Craniofacial Growth. J Clin Med.2020;9(4).

Abdal-Hay A, Thattaruparambil Raveendran N, Fournier B, Ivanovski S. Fabrication of Biocompatible and Bioabsorbable Polycaprolactone/ Magnesium Hydroxide 3D Printed Scaffolds: Degradation and in vitro Osteoblasts Interactions. Composites Part B: Engineering. 2020

Babajko S, Gayrard V, Houari S, Thu Bui A, Barouki R, Niederreither K, Fini JB, Dursun E, Coumoul X. `{`Oral cavity as a target and a marker of environmental exposures: developmental dental defects`}`. Med Sci (Paris). 2020;36(3):225-230.

Babajko S, Lescaille G, Radoï L, Thu Bui A, Baaroun V, Boyer E, Delbosc S,Chardin H, Barouki R, Coumoul X. `{`Oral cavity as a target and a marker ofenvironmental exposures: diseases diagnosed during adulthood`}`. Med Sci (Paris).2020;36(3):231-234.
Gama A, Vargas-Franco JW, Sánchez Mesa DC, Restrepo Bedoya E, Amiaud J, Babajko S, Berdal A, Acevedo AC, Heymann D, Lézot F, Castaneda B. Origins of Alterations to Rankl Null Mutant Mouse Dental Root Development. Int J Mol Sci.2020;21(6).

Merzoug-Larabi M, Youssef I, Bui AT, Legay C, Loiodice S, Lognon S, Babajko S, Ricort JM. Protein Kinase D1 (PKD1) Is a New Functional Non-Genomic Target of Bisphenol A in Breast Cancer Cells. Front Pharmacol. 2020.10:1683.

Youssef I, Ricort JM. Deciphering the Role of Protein Kinase D1 (PKD1) in Cellular Proliferation. Mol Cancer Res. 2019;17(10):1961-1974.

Chekroun M, Cherifi H, Fournier B, Gaultier F, Sitbon IY, Ferre FC, Gogly B. 2019. Oral manifestations of sickle cell disease. Br Dent J. 226(1):27-31..

de La Dure-Molla M, Fournier BP, Manzanares MC, Acevedo AC, Hennekam RC, Friedlander L, Boy-Lefèvre ML, Kerner S, Toupenay S, Garrec P, Vi-Fane B, Felizardo R, Berteretche MV, Jordan L, Ferré F, Clauss F, Jung S, de Chalendar M, Troester S, Kawczynski M, Chaloyard J; International Group of Dental Nomenclature, Manière MC, Berdal A, Bloch-Zupan A. Elements of morphology: Standard terminology for the teeth and classifying genetic dental disorders. Am J Med Genet A. 2019;179(10):1913-1981.

Friedlander L, Berdal A, Boizeau P, Licht BA, Manière MC, Picard A, Azzis O, Vazquez MP, Alberti C, Molla MD. Oral health related quality of life of children and adolescents affected by rare orofacial diseases: a questionnaire-based cohort study. Orphanet J Rare Dis. 2019;14(1):124. doi: 10.1186/s13023-019-1109-

Gama A, Perea L, Yepes C, Betancur JJ, Vargas J, Amiaud J, Babajko S, Lezot F, Castaneda B. `{`Effects of post-natal inhibition of RANKL on molar eruption and root formation in C57BL/6 mice`}`. Orthod Fr. 2019;90(1):55-63.

Houari S, Picard E, Wurtz T, Vennat E, Roubier N, Wu TD, Guerquin-Kern JL, Duttine M, Thuy TT, Berdal A, Babajko S. Disrupted Iron Storage in Dental Fluorosis. J Dent Res. 2019;98(9):994-1001.

Jordan L, Beydon N, Razanamihaja N, Garrec P, Carra MC, Fournier BP, Vi-Fane B, Kerner S, Felizardo R, Boy-Lefèvre ML, De La Dure-Molla M. Translation and cross-cultural validation of the French version of the Sleep-Related Breathing Disorder scale of the Pediatric Sleep Questionnaire. Sleep Med. 2019;58:123-129. https://doi.org/10.1016/j.sleep.2019.02.021

Korah L, Amri N, Bugueno IM, Hotton D, Tenenbaum H, Huck O, Berdal A, Davideau JL. Experimental periodontitis in Msx2 mutant mice induces alveolar bone necrosis. J Periodontol. 2019. https://doi.org/10.1002/JPER.16-0435

Perea-Gomez A, Cases O, Lelièvre V, Pulina MV, Collignon J, Hadjantonakis AK, Kozyraki R. Loss of Cubilin, the intrinsic factor-vitamin B12 receptor, impairs visceral endoderm endocytosis and endodermal patterning in the mouse. Sci Rep. 2019;9(1):10168. doi: 10.1038/s41598-019-46559-0https://www.nature.com/articles/s41598-019-46559-0

Taïhi I, Nassif A, Isaac J, Fournier BP, Ferré F. Head to Knee: Cranial Neural Crest-Derived Cells as Promising Candidates for Human Cartilage Repair. Stem Cells Int. 2019

Vutipongsatorn K, Nagaoka N, Yokoi T, Yoshida T, Kamoi K, Horie S, Uramoto K, Hirata A, Occelli LM, Petersen-Jones SM, Montiani-Ferreira F, Cases O, Kozyraki R, Jonas JB, Ohno-Matsui K. Correlations Between Experimental Myopia Models And Human Pathologic Myopia. Retina. 2019;39(4):621-635.


Current Positions


IADR/PER General Session & Exhibition, July 25-28 , 2018 London, England

Oral presentations: The Paradoxical Phenotype in FAM20A Gene Mutations Amelogenesis Imperfecta and Ectopic Mineralization in Soft Tissues
A Debate in Oral Pathophysiology: Would Osteoblasts be Different in Jaws and Long Bones

Oral Presentation: Biomimetics Properties Analysis of a Brushite-based Material for Pulp Healing

Poster Presentation: Development of a New Biomimetic Material for Bone Regeneration

Academic recognition

Join one of the most recognized universities world wide

Practical Teaching

Organisation of a ``Research Initiation`` value unit at the Faculty of Dentistry (Garanciere) of the Paris Diderot University.
These courses are intended for undergraduate students.
D.Hotton and A.Bolanos